IBX5980432E7F390 Test May Unusualiate Mesothelioma from Benign Conditions - Health Cancer

Test May Unusualiate Mesothelioma from Benign Conditions

Test May Unusualiate Mesothelioma from Benign Conditions

One of the largegest challenges for patients and clinicians dealing with malignant pleural mesothelioma is only, merely, solely getting a definitive diagnosis. Although mesothelioma is shutly associated with asbestos, symptoms may not demonstrate up until decades after expocertain, malord it hard to link the cause and effect. When symptoms such as chest pain and shortness of breath do arrise, they are often attributed to other, less serious causes.

But a recent article in Lung Clevercer focuses on a promitune new way to aid unusualiate mesothelioma from other conditions with similar charbehaveeristics. Researchers at the University of Chicago and clevercer centers in the UK, France, and Japan say a glucose vehicle protein called GLUT-1 was present in half of the epithelioid mesothelioma cells tested and three quarters of the sarcomatoid mesothelioma cells.

For this retrospective learn, the authors performed immunohistochemical staining for the presence of GLUT-1 in tissue samples from 70 people with mesothelioma, 31 people with a benign condition called mesothelial hyperplasia, and 29 people with benign fibrotune pleuritis. Forty-one of the mesothelioma samples were from patients with the epithelioid variety and 29 from those who had sarcomatoid mesothelioma. Slides from all cell samples were scored by pathologists based on the gratuityage of cells in the samples that were positive for GLUT-1.

The learn found that all benign samples were negative for GLUT-1. However, 58% of the malignant mesothelioma samples stained positive for GLUT-1, to varying degrees. Twenty-one of the 41 epithelioid mesothelioma cell samples were positive for GLUT-1 and 21 of the 29 sarcomatoid mesothelioma samples were positive. In addition, there were 3 biphasic mesothelioma samples (the least general type of mesothelioma), all of which tested positive for GLUT-1.

The authors caution that GLUT-1 testing does have its limitations and that a negative stain does not necessarily exclude the diagnosis of mesothelioma, but say it could be an important new diagnostic tool. “As with all immunohistochemical stains used for diagnostic purposes, GLUT-1 has to be a part of a panel and the results interpreted in the context of clinical, radiological, and histological findings,” they concluded.


Husain, AN, et al, “How aidful is GLUT-1 in unusualiating mesothelial hyperplasia and fibrotune pleuritis from epithelioid and sarcomatoid mesotheliomas? An international collaborative learn”, December 30, 2013, Lung Clevercer, Epub head of print.

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